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Total Biosynthesis for Milligram-Scale Production of Etoposide Intermediates in a Plant Chassis

Etoposide is a plant-derived drug used clinically to treat several forms of cancer. Recent shortages of etoposide demonstrate the need for a more dependable production method to replace the semisynthetic method currently in place, which relies on extraction of a precursor natural product from Himala...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Schultz, Bailey J., Kim, Seung Yeon, Lau, Warren, Sattely, Elizabeth S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380830/
https://ncbi.nlm.nih.gov/pubmed/31755709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b10717
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