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Interfacial inhibitors: targeting macromolecular complexes

Interfacial inhibitors belong to a broad class of natural products and synthetic drugs that are commonly used to treat cancers as well as bacterial and HIV infections. They bind selectively to interfaces as macromolecular machines assemble and are set in motion. The bound drugs transiently arrest th...

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Bibliografske podrobnosti
izdano v:Nat Rev Drug Discov
Main Authors: Pommier, Yves, Marchand, Christophe
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380715/
https://ncbi.nlm.nih.gov/pubmed/22173432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd3404
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