KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells

Interactions of KRAB (Krüppel-associated box)-associated protein KAP1 [also known as TRIM28 (tripartite motif containing protein 28)] with DNA-binding KRAB zinc finger (KRAB-ZF) proteins silence many transposable elements during embryogenesis. However, in some cancers, TRIM28 is upregulated and inte...

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Vydáno v:NAR Cancer
Hlavní autoři: Kumar, Janani, Kaur, Gundeep, Ren, Ren, Lu, Yue, Lin, Kevin, Li, Jia, Huang, Yun, Patel, Anamika, Barton, Michelle C, Macfarlan, Todd, Zhang, Xing, Cheng, Xiaodong
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Cancer Gene Regulation, Chromatin, and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380489/
https://ncbi.nlm.nih.gov/pubmed/32743551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa007
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