Structure and functional reselection of the Mango-III fluorogenic RNA aptamer

Several turn-on RNA aptamers that activate small molecule fluorophores have been selected in vitro. Among these, the ~30 nucleotide Mango-III is notable because it binds the thiazole orange derivative TO1-Biotin with high affinity and fluoresces brightly (quantum yield 0.55). Uniquely among related...

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Gepubliceerd in:Nat Chem Biol
Hoofdauteurs: Trachman, Robert J., Autour, Alexis, Jeng, Sunny C.Y., Abdolahzadeh, Amir, Andreoni, Alessio, Cojocaru, Razvan, Garipov, Ramil, Dolgosheina, Elena V., Knutson, Jay R., Ryckelynck, Michael, Unrau, Peter J., Ferré-D’Amaré, Adrian R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380332/
https://ncbi.nlm.nih.gov/pubmed/30992561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0267-9
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