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Structure and functional reselection of the Mango-III fluorogenic RNA aptamer
Several turn-on RNA aptamers that activate small molecule fluorophores have been selected in vitro. Among these, the ~30 nucleotide Mango-III is notable because it binds the thiazole orange derivative TO1-Biotin with high affinity and fluoresces brightly (quantum yield 0.55). Uniquely among related...
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| Izdano u: | Nat Chem Biol |
|---|---|
| Glavni autori: | , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7380332/ https://ncbi.nlm.nih.gov/pubmed/30992561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0267-9 |
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