Hydroxyurea Scavenges Free Radicals and Induces the Expression of Antioxidant Genes in Human Cell Cultures Treated With Hemin

The excessive release of heme during hemolysis contributes to the severity of sickle cell anemia (SCA) by exacerbating hemoglobin S (HbS) autoxidation, inflammation and systemic tissue damage. The present study investigated the effect of hydroxyurea (HU) on free radical neutralization and its stimul...

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Publicat a:Front Immunol
Autors principals: Santana, Sânzio Silva, Pitanga, Thassila Nogueira, de Santana, Jeanne Machado, Zanette, Dalila Lucíola, Vieira, Jamile de Jesus, Yahouédéhou, Sètondji Cocou Modeste Alexandre, Adanho, Corynne Stéphanie Ahouefa, Viana, Sayonara de Melo, Luz, Nivea Farias, Borges, Valeria Matos, Goncalves, Marilda Souza
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380266/
https://ncbi.nlm.nih.gov/pubmed/32765515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01488
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