Sickle Cell Anemia: Variants in the CYP2D6, CAT, and SLC14A1 Genes Are Associated With Improved Hydroxyurea Response

Differences in hydroxyurea response in sickle cell anemia may arise due to a series of factors with genetic factors appearing to be predominant. This study aims to investigate the effects of single nucleotide polymorphisms in genes encoding drug-metabolizing enzymes and solute carriers on hydroxyure...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Yahouédéhou, Sètondji Cocou Modeste Alexandre, Neres, Joelma Santana dos Santos, da Guarda, Caroline Conceição, Carvalho, Suellen Pinheiro, Santiago, Rayra Pereira, Figueiredo, Camylla Vilas Boas, Fiuza, Luciana Magalhães, Ndidi, Uche Samuel, de Oliveira, Rodrigo Mota, Fonseca, Cleverson Alves, Nascimento, Valma Maria Lopes, Rocha, Larissa Carneiro, Adanho, Corynne Stéphanie Ahouéfa, da Rocha, Tiago Santos Carvalho, Adorno, Elisângela Vitória, Goncalves, Marilda Souza
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510454/
https://ncbi.nlm.nih.gov/pubmed/33013391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.553064
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