Sickle Cell Anemia: Variants in the CYP2D6, CAT, and SLC14A1 Genes Are Associated With Improved Hydroxyurea Response

Differences in hydroxyurea response in sickle cell anemia may arise due to a series of factors with genetic factors appearing to be predominant. This study aims to investigate the effects of single nucleotide polymorphisms in genes encoding drug-metabolizing enzymes and solute carriers on hydroxyure...

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Vydáno v:Front Pharmacol
Hlavní autoři: Yahouédéhou, Sètondji Cocou Modeste Alexandre, Neres, Joelma Santana dos Santos, da Guarda, Caroline Conceição, Carvalho, Suellen Pinheiro, Santiago, Rayra Pereira, Figueiredo, Camylla Vilas Boas, Fiuza, Luciana Magalhães, Ndidi, Uche Samuel, de Oliveira, Rodrigo Mota, Fonseca, Cleverson Alves, Nascimento, Valma Maria Lopes, Rocha, Larissa Carneiro, Adanho, Corynne Stéphanie Ahouéfa, da Rocha, Tiago Santos Carvalho, Adorno, Elisângela Vitória, Goncalves, Marilda Souza
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510454/
https://ncbi.nlm.nih.gov/pubmed/33013391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.553064
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