Hydroxyurea Scavenges Free Radicals and Induces the Expression of Antioxidant Genes in Human Cell Cultures Treated With Hemin

The excessive release of heme during hemolysis contributes to the severity of sickle cell anemia (SCA) by exacerbating hemoglobin S (HbS) autoxidation, inflammation and systemic tissue damage. The present study investigated the effect of hydroxyurea (HU) on free radical neutralization and its stimul...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Santana, Sânzio Silva, Pitanga, Thassila Nogueira, de Santana, Jeanne Machado, Zanette, Dalila Lucíola, Vieira, Jamile de Jesus, Yahouédéhou, Sètondji Cocou Modeste Alexandre, Adanho, Corynne Stéphanie Ahouefa, Viana, Sayonara de Melo, Luz, Nivea Farias, Borges, Valeria Matos, Goncalves, Marilda Souza
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380266/
https://ncbi.nlm.nih.gov/pubmed/32765515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01488
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