Spectrum of TP53 Mutations in BRCA1/2 Associated High-Grade Serous Ovarian Cancer

Objective: Mutations in TP53 lead to loss of function (LOF) or gain of function (GOF) of the corresponding protein p53 and produce a different effect on the tumor. Our goal was to determine the spectrum of somatic TP53 variants in BRCA1/2 associated high-grade serous ovarian cancer (HGSOC). Methods:...

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Vydáno v:Front Oncol
Hlavní autoři: Boyarskikh, Ulyana A., Gulyaeva, L. F., Avdalyan, A. M., Kechin, A. A., Khrapov, E. A., Lazareva, D. G., Kushlinskii, N. E., Melkonyan, A., Arakelyan, A., Filipenko, Maxim Leonidovich
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378769/
https://ncbi.nlm.nih.gov/pubmed/32766142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01103
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