Spectrum of TP53 Mutations in BRCA1/2 Associated High-Grade Serous Ovarian Cancer

Objective: Mutations in TP53 lead to loss of function (LOF) or gain of function (GOF) of the corresponding protein p53 and produce a different effect on the tumor. Our goal was to determine the spectrum of somatic TP53 variants in BRCA1/2 associated high-grade serous ovarian cancer (HGSOC). Methods:...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Front Oncol
Auteurs principaux: Boyarskikh, Ulyana A., Gulyaeva, L. F., Avdalyan, A. M., Kechin, A. A., Khrapov, E. A., Lazareva, D. G., Kushlinskii, N. E., Melkonyan, A., Arakelyan, A., Filipenko, Maxim Leonidovich
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Oncology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378769/
https://ncbi.nlm.nih.gov/pubmed/32766142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01103
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires