The CD28 Transmembrane Domain Contains an Essential Dimerization Motif

CD28 plays a critical role in regulating immune responses both by enhancing effector T cell activation and differentiation and controlling the development and function of regulatory T cells. CD28 is expressed at the cell surface as a disulfide linked homodimer that is thought to bind ligand monovale...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Leddon, Scott A., Fettis, Margaret M., Abramo, Kristin, Kelly, Ryan, Oleksyn, David, Miller, Jim
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378745/
https://ncbi.nlm.nih.gov/pubmed/32765524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01519
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