Differential Transmembrane Domain GXXXG Motif Pairing Impacts Major Histocompatibility Complex (MHC) Class II Structure

Major histocompatibility complex (MHC) class II molecules exhibit conformational heterogeneity, which influences their ability to stimulate CD4 T cells and drive immune responses. Previous studies suggest a role for the transmembrane domain of the class II αβ heterodimer in determining molecular str...

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Detalhes bibliográficos
Principais autores: Dixon, Ann M., Drake, Lisa, Hughes, Kelly T., Sargent, Elizabeth, Hunt, Danielle, Harton, Jonathan A., Drake, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002079/
https://ncbi.nlm.nih.gov/pubmed/24619409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.516997
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