CO-STIMULATION BLOCKADE DISRUPTS CD4(+) T-CELL MEMORY PATHWAYS AND UNCOUPLES THEIR LINK TO DECLINE IN β-CELL FUNCTION IN TYPE 1 DIABETES

We previously reported that co-stimulation blockade by abatacept limits the decline of β-cell function and the frequency of circulating CD4(+) central memory (CD45RO(+)CD62L(+)) T (T(CM)) cells in new-onset type 1 diabetes. In human subjects receiving placebo we found a significant association betwe...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Eichmann, Martin, Baptista, Roman, Ellis, Richard J., Heck, Susanne, Peakman, Mark, Beam, Craig A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378361/
https://ncbi.nlm.nih.gov/pubmed/32404353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901439
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