Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline

We previously reported that continuous 24-month costimulation blockade by abatacept significantly slows the decline of β-cell function after diagnosis of type 1 diabetes. In a mechanistic extension of that study, we evaluated peripheral blood immune cell subsets (CD4, CD8-naive, memory and activated...

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Detalhes bibliográficos
Main Authors: Orban, Tihamer, Beam, Craig A., Xu, Ping, Moore, Keith, Jiang, Qi, Deng, Jun, Muller, Sarah, Gottlieb, Peter, Spain, Lisa, Peakman, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2014
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171657/
https://ncbi.nlm.nih.gov/pubmed/24834977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0047
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