Co-Stimulation Modulation with Abatacept in Patients with Recent-Onset Type 1 Diabetes: A Randomised Double-Masked Controlled Trial

BACKGROUND: The immunopathogenesis of type 1 diabetes mellitus (T1DM) is associated with T-lymphocyte autoimmunity. To be fully active, immune T-lymphocytes require a co-stimulatory signal in addition to the main antigen driven signal. Abatacept modulates co-stimulation andprevents full T-lymphocyte...

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Main Authors: Orban, Tihamer, Bundy, Brian, Becker, Dorothy J., DiMeglio, Linda A., Gitelman, Stephen E., Goland, Robin, Gottlieb, Peter A., Greenbaum, Carla J., Marks, Jennifer B., Monzavi, Roshanak, Moran, Antoinette, Raskin, Philip, Rodriguez, Henry, Russell, William E., Schatz, Desmond, Wherrett, Diane, Wilson, Darrell M., Krischer, Jeffrey P., Skyler, Jay S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462593/
https://ncbi.nlm.nih.gov/pubmed/21719096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(11)60886-6
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