Antigen-Based Therapy with Glutamic Acid Decarboxylase (GAD) Vaccine in Patients with Recent-Onset Type 1 Diabetes: A Randomised Double-Masked Controlled Trial

BACKGROUND: Type 1 diabetes (T1DM) is an autoimmune disease leading to destruction of insulin producing beta cells and life-long requirement for insulin therapy. Glutamic acid decarboxylase (GAD) is a major target of this immune response. Studies in animal models of autoimmunity have shown that trea...

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Detalhes bibliográficos
Main Authors: Wherrett, Diane K., Bundy, Brian, DiMeglio, Linda A., Gitelman, Stephen E., Goland, Robin, Gottlieb, Peter A., Greenbaum, Carla J., Herold, Kevan C., Marks, Jennifer B., Monzavi, Roshanak, Moran, Antoinette, Orban, Tihamer, Palmer, Jerry P., Raskin, Philip, Rodriguez, Henry, Schatz, Desmond, Wilson, Darrell M., Krischer, Jeffrey P., Skyler, Jay S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580128/
https://ncbi.nlm.nih.gov/pubmed/21714999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(11)60895-7
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