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CO-STIMULATION BLOCKADE DISRUPTS CD4(+) T-CELL MEMORY PATHWAYS AND UNCOUPLES THEIR LINK TO DECLINE IN β-CELL FUNCTION IN TYPE 1 DIABETES
We previously reported that co-stimulation blockade by abatacept limits the decline of β-cell function and the frequency of circulating CD4(+) central memory (CD45RO(+)CD62L(+)) T (T(CM)) cells in new-onset type 1 diabetes. In human subjects receiving placebo we found a significant association betwe...
Shranjeno v:
| izdano v: | J Immunol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7378361/ https://ncbi.nlm.nih.gov/pubmed/32404353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901439 |
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