Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages

Upon activation, macrophages undergo extensive metabolic rewiring(1,2). Production of itaconate through the inducible enzyme IRG1 is a key hallmark of this process(3). Itaconate inhibits succinate dehydrogenase (SDH)(4,5), has electrophilic properties(6), and is associated with a change in cytokine...

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Bibliografski detalji
Izdano u:Nat Metab
Glavni autori: Swain, Amanda, Bambouskova, Monika, Kim, Hyeryun, Andhey, Prabhakar Sairam, Duncan, Dustin, Auclair, Karine, Chubukov, Victor, Simons, Donald M., Roddy, Thomas P., Stewart, Kelly M., Artyomov, Maxim N.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378276/
https://ncbi.nlm.nih.gov/pubmed/32694786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-0210-0
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