Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

Metabolic regulation has been recognized as a powerful principle guiding immune responses. Inflammatory macrophages undergo extensive metabolic rewiring(1) marked by the production of substantial amounts of itaconate, which has recently been described as an immunoregulatory metabolite(2). Itaconate...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Bambouskova, Monika, Gorvel, Laurent, Lampropoulou, Vicky, Sergushichev, Alexey, Loginicheva, Ekaterina, Johnson, Kendall, Korenfeld, Daniel, Mathyer, Mary Elizabeth, Kim, Hyeryun, Huang, Li-Hao, Duncan, Dustin, Bregman, Howard, Keskin, Abdurrahman, Santeford, Andrea, Apte, Rajendra S., Sehgal, Raghav, Johnson, Britney, Amarasinghe, Gaya K., Soares, Miguel P., Satoh, Takashi, Akira, Shizuo, Hai, Tsonwin, de Guzman Strong, Cristina, Auclair, Karine, Roddy, Thomas P., Biller, Scott A., Jovanovic, Marko, Klechevsky, Eynav, Stewart, Kelly M., Randolph, Gwendalyn J., Artyomov, Maxim N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037913/
https://ncbi.nlm.nih.gov/pubmed/29670287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0052-z
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