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Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures

Changes in bulk transcriptional profiles of heterogeneous samples often reflect changes in proportions of individual cell types. Several robust techniques have been developed to dissect the composition of such mixed samples given transcriptional signatures of the pure components or their proportions...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Zaitsev, Konstantin, Bambouskova, Monika, Swain, Amanda, Artyomov, Maxim N.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525259/
https://ncbi.nlm.nih.gov/pubmed/31101809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09990-5
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