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Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures

Changes in bulk transcriptional profiles of heterogeneous samples often reflect changes in proportions of individual cell types. Several robust techniques have been developed to dissect the composition of such mixed samples given transcriptional signatures of the pure components or their proportions...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zaitsev, Konstantin, Bambouskova, Monika, Swain, Amanda, Artyomov, Maxim N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525259/
https://ncbi.nlm.nih.gov/pubmed/31101809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09990-5
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