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A FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases
Tankyrases catalyse poly-ADP-ribosylation of their binding partners and the modification serves as a signal for the subsequent proteasomal degradation of these proteins. Tankyrases thereby regulate the turnover of many proteins involved in multiple and diverse cellular processes, such as mitotic spi...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7378079/ https://ncbi.nlm.nih.gov/pubmed/32704068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69229-y |
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