An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses

CD137 is a costimulatory receptor expressed on natural killer cells, T cells, and subsets of dendritic cells. An agonistic monoclonal antibody (mAb) against CD137 has been used to reduce tumor burden or reverse autoimmunity in animal models and clinical trials. Here, we show that mice treated with a...

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Veröffentlicht in:Cell Rep Med
Hauptverfasser: Hong, Jun P., Reynoso, Glennys V., Andhey, Prabhakar S., Swain, Amanda, Turner, Jackson S., Boon, Adrianus C.M., Krammer, Florian, Ellebedy, Ali H., Zanini, Fabio, Artyomov, Maxim, Hickman, Heather D., Diamond, Michael S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375459/
https://ncbi.nlm.nih.gov/pubmed/32699843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100035
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