Ethanol exposure increases mutation rate through error-prone polymerases

Ethanol is a ubiquitous environmental stressor that is toxic to all lifeforms. Here, we use the model eukaryote Saccharomyces cerevisiae to show that exposure to sublethal ethanol concentrations causes DNA replication stress and an increased mutation rate. Specifically, we find that ethanol slows do...

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Foilsithe in:Nat Commun
Main Authors: Voordeckers, Karin, Colding, Camilla, Grasso, Lavinia, Pardo, Benjamin, Hoes, Lore, Kominek, Jacek, Gielens, Kim, Dekoster, Kaat, Gordon, Jonathan, Van der Zande, Elisa, Bircham, Peter, Swings, Toon, Michiels, Jan, Van Loo, Peter, Nuyts, Sandra, Pasero, Philippe, Lisby, Michael, Verstrepen, Kevin J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374746/
https://ncbi.nlm.nih.gov/pubmed/32694532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17447-3
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