Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A

Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. Adaptive mutants are localised on the C-terminal (627-NLS) domains of the PB2 subunit. In particular, mutation of PB2 residue 627 from E to K rescues polymerase activity in mammalian cells. A host...

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Udgivet i:Nat Commun
Main Authors: Camacho-Zarco, Aldo R., Kalayil, Sissy, Maurin, Damien, Salvi, Nicola, Delaforge, Elise, Milles, Sigrid, Jensen, Malene Ringkjøbing, Hart, Darren J., Cusack, Stephen, Blackledge, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374565/
https://ncbi.nlm.nih.gov/pubmed/32694517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17407-x
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