Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions

Intrinsically disordered linkers provide multi-domain proteins with degrees of conformational freedom that are often essential for function. These highly dynamic assemblies represent a significant fraction of all proteomes, and deciphering the physical basis of their interactions represents a consid...

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Publicat a:Front Mol Biosci
Autors principals: Delaforge, Elise, Milles, Sigrid, Huang, Jie-rong, Bouvier, Denis, Jensen, Malene Ringkjøbing, Sattler, Michael, Hart, Darren J., Blackledge, Martin
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Molecular Biosciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020063/
https://ncbi.nlm.nih.gov/pubmed/27679800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00054
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