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Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A
Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. Adaptive mutants are localised on the C-terminal (627-NLS) domains of the PB2 subunit. In particular, mutation of PB2 residue 627 from E to K rescues polymerase activity in mammalian cells. A host...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7374565/ https://ncbi.nlm.nih.gov/pubmed/32694517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17407-x |
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