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Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets
Development of small molecule compounds that target several cancer drivers has shown great therapeutic potential. Here, we developed a new generation of highly potent thienopyranone (TP)-based inhibitors for the BET bromodomains (BDs) of the transcriptional regulator BRD4 that have the ability to si...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7374098/ https://ncbi.nlm.nih.gov/pubmed/32694708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68964-6 |
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