KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression

BACKGROUND: Kaposi’s Sarcoma Herpesvirus (KSHV) is a gammaherpesvirus strongly linked to human cancer. The virus is also able to induce immune suppression, effect that contributes to onset/progression of the viral-associated malignancies. As KSHV may infect macrophages and these cells abundantly inf...

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Publicado en:Br J Cancer
Main Authors: Gilardini Montani, Maria Saveria, Falcinelli, Luca, Santarelli, Roberta, Granato, Marisa, Romeo, Maria Anele, Cecere, Nives, Gonnella, Roberta, D’Orazi, Gabriella, Faggioni, Alberto, Cirone, Mara
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374093/
https://ncbi.nlm.nih.gov/pubmed/32418990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0872-0
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