Optimising the dose of clonidine to achieve sedation in intensive care unit patients with population pharmacokinetics

AIMS: The aim of this study was to investigate the population pharmacokinetics (PK) of clonidine in intensive care unit (ICU) patients in order to develop a dosing regimen for sedation. METHODS: We included 24 adult mechanically ventilated, sedated patients from a mixed medical and surgical ICU. Int...

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Publicado en:Br J Clin Pharmacol
Autores principales: Cloesmeijer, Michael E., van den Oever, Huub L.A., Mathôt, Ron A.A., Zeeman, Marieke, Kruisdijk‐Gerritsen, Arriette, Bles, Carmen M.A., Nassikovker, Polina, de Meijer, Arthur R., van Steveninck, Fred L., Arbouw, Maurits E.L.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373711/
https://ncbi.nlm.nih.gov/pubmed/32150285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14273
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