Population pharmacokinetics of intravenous clonidine for sedation during paediatric extracorporeal membrane oxygenation and continuous venovenous hemofiltration

AIMS: Clonidine is used for sedation in the paediatric intensive care unit. Extracorporeal membrane oxygenation (ECMO) provides temporary support if respiratory and cardiac function is threatened. ECMO influences the pharmacokinetics of drugs. Clonidine during paediatric ECMO cannot be effectively t...

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Publicado en:Br J Clin Pharmacol
Autores principales: Kleiber, Niina, Mathôt, Ron A. A., Ahsman, Maurice J., Wildschut, Enno D., Tibboel, Dick, de Wildt, Saskia N.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Pharmacokinetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427246/
https://ncbi.nlm.nih.gov/pubmed/28078682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13235
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