Optimising the dose of clonidine to achieve sedation in intensive care unit patients with population pharmacokinetics

AIMS: The aim of this study was to investigate the population pharmacokinetics (PK) of clonidine in intensive care unit (ICU) patients in order to develop a dosing regimen for sedation. METHODS: We included 24 adult mechanically ventilated, sedated patients from a mixed medical and surgical ICU. Int...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Cloesmeijer, Michael E., van den Oever, Huub L.A., Mathôt, Ron A.A., Zeeman, Marieke, Kruisdijk‐Gerritsen, Arriette, Bles, Carmen M.A., Nassikovker, Polina, de Meijer, Arthur R., van Steveninck, Fred L., Arbouw, Maurits E.L.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373711/
https://ncbi.nlm.nih.gov/pubmed/32150285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14273
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