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Automated Synthesis and Purification of Guanidine-Backbone Oligonucleotides
This protocol describes a method based on iodine and a base as mild coupling reagents to synthetize deoxyribonucleic guanidines (DNGs)—oligodeoxynucleotide analogues with a guanidine backbone. DNGs display unique properties, such as high cellular uptake with low toxicity and increased stability agai...
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| Publicado en: | Curr Protoc Nucleic Acid Chem |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7373344/ https://ncbi.nlm.nih.gov/pubmed/32530578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpnc.110 |
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