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Mercury-Free Automated Synthesis of Guanidinium Backbone Oligonucleotides
A new method for synthesizing deoxynucleic guanidine (DNG) oligonucleotides that uses iodine as a mild and inexpensive coupling reagent is reported. This method eliminates the need for the toxic mercury salts and pungent thiophenol historically used in methods aimed at preparing DNG oligonucleotides...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7027944/ https://ncbi.nlm.nih.gov/pubmed/31840508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b09937 |
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