Peptide vaccination directed against IDO1-expressing immune cells elicits CD8(+) and CD4(+) T-cell-mediated antitumor immunity and enhanced anti-PD1 responses

BACKGROUND: The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which subverts T-cell immunity at multiple levels, is itself subject to inherent T-cell reactivity. This intriguing deviation from central tolerance has been interpreted as counterbalancing IDO1-mediated immunosuppr...

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Bibliographic Details
Published in:J Immunother Cancer
Main Authors: Dey, Souvik, Sutanto-Ward, Erika, Kopp, Katharina L, DuHadaway, James, Mondal, Arpita, Ghaban, Dema, Lecoq, Inés, Zocca, Mai-Britt, Merlo, Lauren M F, Mandik-Nayak, Laura, Andersen, Mads Hald, Pedersen, Ayako Wakatsuki, Muller, Alexander J
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2020
Subjects:
Basic Tumor Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373332/
https://ncbi.nlm.nih.gov/pubmed/32690770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000605
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