TLR9 activation induces aberrant IgA glycosylation via APRIL- and IL-6-mediated pathways in IgA nephropathy

Galactose-deficient IgA1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). However, the pathogenic mechanisms driving Gd-IgA1 production have not been fully elucidated. Innate-immune activation via Toll-like receptor 9 (TLR9) is known to be involved in Gd-IgA1 production....

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Detalhes bibliográficos
Publicado no:Kidney Int
Main Authors: Makita, Yuko, Suzuki, Hitoshi, Kano, Toshiki, Takahata, Akiko, Julian, Bruce A., Novak, Jan, Suzuki, Yusuke
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372907/
https://ncbi.nlm.nih.gov/pubmed/31748116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2019.08.022
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