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Tubulysin Synthesis Featuring Stereoselective Catalysis and Highly Convergent Multicomponent Assembly
[Image: see text] A concise and modular total synthesis of the highly potent N(14)-desacetoxytubulysin H (1) has been accomplished in 18 steps in an overall yield of up to 30%. Our work highlights the complexity–augmenting and route-shortening power of diastereoselective multicomponent reaction (MCR...
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| Udgivet i: | Org Lett |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical Society
2020
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7372561/ https://ncbi.nlm.nih.gov/pubmed/32584589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c01718 |
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