Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding

The β-cell protein synthetic machinery is dedicated to the production of mature insulin, which requires the proper folding and trafficking of its precursor, proinsulin. The complete network of proteins that mediate proinsulin folding and advancement through the secretory pathway, however, remains po...

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Опубликовано в: :Diabetes
Главные авторы: Tran, Duc T., Pottekat, Anita, Mir, Saiful A., Loguercio, Salvatore, Jang, Insook, Campos, Alexandre Rosa, Scully, Kathleen M., Lahmy, Reyhaneh, Liu, Ming, Arvan, Peter, Balch, William E., Kaufman, Randal J., Itkin-Ansari, Pamela
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2020
Предметы:
Islet Studies
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372081/
https://ncbi.nlm.nih.gov/pubmed/32457219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0245
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