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Quantitative Interpretation of Solvent Paramagnetic Relaxation for Probing Protein–Cosolute Interactions

Protein–small cosolute molecule interactions are ubiquitous and known to modulate the solubility, stability, and function of many proteins. Characterization of such transient weak interactions at atomic resolution remains challenging. In this work, we develop a simple and practical NMR method for ex...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Okuno, Yusuke, Szabo, Attila, Clore, G. Marius
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372007/
https://ncbi.nlm.nih.gov/pubmed/32286812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c00747
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