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Interplay between Conformational Selection and Induced Fit in Multidomain Protein-Ligand Binding Probed by Paramagnetic Relaxation Enhancement
The binding of ligands and substrates to proteins has been extensively studied for many years and can be described, in its simplest form, by two limiting mechanisms: conformational selection and induced fit. Conformational selection involves binding of ligand to a pre-existing sparsely-populated con...
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| Natura: | Artigo |
| Lingua: | Inglês |
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2013
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3944927/ https://ncbi.nlm.nih.gov/pubmed/24070540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2013.08.006 |
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