Modeling Pathway Dynamics of the Skeletal Muscle Response to Intravenous Methylprednisolone (MPL) Administration in Rats: Dosing and Tissue Effects

A model-based approach for the assessment of pathway dynamics is explored to characterize metabolic and signaling pathway activity changes characteristic of the dosing-dependent differences in response to methylprednisolone in muscle. To consistently compare dosing-induced changes we extend the prin...

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Опубликовано в: :Front Bioeng Biotechnol
Главные авторы: Acevedo, Alison, DuBois, Debra, Almon, Richard R., Jusko, William J., Androulakis, Ioannis P.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Bioengineering and Biotechnology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371857/
https://ncbi.nlm.nih.gov/pubmed/32760706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.00759
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