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Unraveling the Complexity of γ-Secretase
γ-Secretase was initially defined as a proteolytic activity that cleaves within the transmembrane of the amyloid precursor protein (APP) to produce the amyloid β-peptide of Alzheimer’s disease. The discovery of mutations in APP and the presenilins associated with familial Alzheimer’s disease and the...
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| Publicado no: | Semin Cell Dev Biol |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7371508/ https://ncbi.nlm.nih.gov/pubmed/31980377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2020.01.005 |
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