Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Previous studies in the Csf1r(+/−) mouse model of ALSP hypothesized a central role of elevated cerebral Csf2 expression. Here, we show that monoallelic deletion of Csf2 rescues most beha...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Chitu, Violeta, Biundo, Fabrizio, Shlager, Gabriel G.L., Park, Eun S., Wang, Ping, Gulinello, Maria E., Gokhan, Sxölen, Ketchum, Harmony C., Saha, Kusumika, DeTure, Michael A., Dickson, Dennis W., Wszolek, Zbignew K., Zheng, Deyou, Croxford, Andrew L., Becher, Burkhard, Sun, Daqian, Mehler, Mark F., Stanley, E. Richard
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370656/
https://ncbi.nlm.nih.gov/pubmed/32130903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.028
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker