Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Previous studies in the Csf1r(+/−) mouse model of ALSP hypothesized a central role of elevated cerebral Csf2 expression. Here, we show that monoallelic deletion of Csf2 rescues most beha...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Chitu, Violeta, Biundo, Fabrizio, Shlager, Gabriel G.L., Park, Eun S., Wang, Ping, Gulinello, Maria E., Gokhan, Sxölen, Ketchum, Harmony C., Saha, Kusumika, DeTure, Michael A., Dickson, Dennis W., Wszolek, Zbignew K., Zheng, Deyou, Croxford, Andrew L., Becher, Burkhard, Sun, Daqian, Mehler, Mark F., Stanley, E. Richard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370656/
https://ncbi.nlm.nih.gov/pubmed/32130903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.028
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