Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Previous studies in the Csf1r(+/−) mouse model of ALSP hypothesized a central role of elevated cerebral Csf2 expression. Here, we show that monoallelic deletion of Csf2 rescues most beha...

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Published in:Cell Rep
Main Authors: Chitu, Violeta, Biundo, Fabrizio, Shlager, Gabriel G.L., Park, Eun S., Wang, Ping, Gulinello, Maria E., Gokhan, Sxölen, Ketchum, Harmony C., Saha, Kusumika, DeTure, Michael A., Dickson, Dennis W., Wszolek, Zbignew K., Zheng, Deyou, Croxford, Andrew L., Becher, Burkhard, Sun, Daqian, Mehler, Mark F., Stanley, E. Richard
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370656/
https://ncbi.nlm.nih.gov/pubmed/32130903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.028
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