Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism

Second generation TRAIL-based therapeutics, combined with sensitising co-treatments, have recently entered clinical trials. However, reliable response predictors for optimal patient selection are not yet available. Here, we demonstrate that a novel and translationally relevant hexavalent TRAIL recep...

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Vydáno v:Cell Death Differ
Hlavní autoři: Vetma, Vesna, Guttà, Cristiano, Peters, Nathalie, Praetorius, Christian, Hutt, Meike, Seifert, Oliver, Meier, Friedegund, Kontermann, Roland, Kulms, Dagmar, Rehm, Markus
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370234/
https://ncbi.nlm.nih.gov/pubmed/32081986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0512-5
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