Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity

Seven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH(2)) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disul...

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Publicado en:Int J Mol Sci
Autores principales: Ptaszyńska, Natalia, Gucwa, Katarzyna, Olkiewicz, Katarzyna, Heldt, Mateusz, Serocki, Marcin, Stupak, Anna, Martynow, Dorota, Dębowski, Dawid, Gitlin-Domagalska, Agata, Lica, Jan, Łęgowska, Anna, Milewski, Sławomir, Rolka, Krzysztof
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369900/
https://ncbi.nlm.nih.gov/pubmed/32630159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21134696
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