Transport Deficiency Is the Molecular Basis of Candida albicans Resistance to Antifungal Oligopeptides

Oligopeptides incorporating N(3)-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0.05–50 μg mL(-1) range. Uptake by the peptide...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Schielmann, Marta, Szweda, Piotr, Gucwa, Katarzyna, Kawczyński, Marcin, Milewska, Maria J., Martynow, Dorota, Morschhäuser, Joachim, Milewski, Sławomir
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673977/
https://ncbi.nlm.nih.gov/pubmed/29163437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.02154
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