Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells

Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activi...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Lica, Jan Jakub, Wieczór, Miłosz, Grabe, Grzegorz Jan, Heldt, Mateusz, Jancz, Marta, Misiak, Majus, Gucwa, Katarzyna, Brankiewicz, Wioletta, Maciejewska, Natalia, Stupak, Anna, Bagiński, Maciej, Rolka, Krzysztof, Hellmann, Andrzej, Składanowski, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8125035/
https://ncbi.nlm.nih.gov/pubmed/34066491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22094931
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