Route of 41BB/41BBL Costimulation Determines Effector Function of B7-H3-CAR.CD28ζ T Cells

B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs). B7-H3-CARs containing a 41BB costimulatory domain are currently favored by several groups based on preclinical stu...

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Udgivet i:Mol Ther Oncolytics
Main Authors: Nguyen, Phuong, Okeke, Emmanuel, Clay, Michael, Haydar, Dalia, Justice, Julie, O’Reilly, Carla, Pruett-Miller, Shondra, Papizan, James, Moore, Jennifer, Zhou, Sheng, Throm, Robert, Krenciute, Giedre, Gottschalk, Stephen, DeRenzo, Christopher
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369352/
https://ncbi.nlm.nih.gov/pubmed/32728609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.06.018
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