Triterpenoid CDDO-Me induces ROS generation and up-regulates cellular levels of antioxidative enzymes without induction of DSBs in human peripheral blood mononuclear cells

Ionizing radiation produces reactive oxygen species (ROS) leading to cellular DNA damage. Therefore, patients undergoing radiation therapy or first responders in radiological accident scenarios could both benefit from the identification of specifically acting pharmacological radiomitigators. The syn...

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Bibliografiske detaljer
Udgivet i:Radiat Environ Biophys
Main Authors: Beinke, Christina, Scherthan, Harry, Port, Matthias, Popp, Tanja, Hermann, Cornelius, Eder, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2020
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369132/
https://ncbi.nlm.nih.gov/pubmed/32409897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00411-020-00847-w
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