Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells

BACKGROUND: Mesenchymal stem/stromal cells (MSC) accumulate and reside in tumor sites. METHODS: Taking advantage of this feature in anticancer therapy, immortalized murine MSC (iMSC) were genetically altered to produce chemokine (C-C motif) ligand 19 (iMSC/CCL19), which attracts dendritic cells (DC)...

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Bibliografske podrobnosti
izdano v:J Immunother Cancer
Main Authors: Iida, Yuichi, Yoshikawa, Rintaro, Murata, Akihiko, Kotani, Hitoshi, Kazuki, Yasuhiro, Oshimura, Mitsuo, Matsuzaki, Yumi, Harada, Mamoru
Format: Artigo
Jezik:Inglês
Izdano: BMJ Publishing Group 2020
Teme:
Immune Cell Therapies and Immune Cell Engineering
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368496/
https://ncbi.nlm.nih.gov/pubmed/32675195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000582
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